产品
编 号:F288592
分子式:C21H28O6
分子量:376.44
产品类型
结构图
CAS No: 2410-60-8
联系客服
产品详情
生物活性:
18-Oxocortisol is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). 18-Oxocortisol is a naturally occurring mineralocorticoid agonist. 18-Oxocortisol is a biomarker in adrenal vein sampling.
体内研究:
Administration of 18-oxocortisol to rats induces a mineralocorticoid-type hypertension with hypokalemia, cardiac and renal enlargement and cardiovascular lesions. Administration of 18-oxocortisol to sheep also causes a rapid increase in blood pressure. However, the doses required for increasing blood pressure are high.