产品
编 号:F290410
分子式:C35H34Cl2N4O8
分子量:709.57
产品类型
结构图
CAS No: 245075-84-7
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产品详情
生物活性:
LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.
体内研究:
LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.Animal Model:Male ZDF rats (13 to 40 weeks)
Dosage:50 mg/L
Administration:P.O. for 27 weeks
Result:Significantly reduced plasma triacylglycerol and cholesterol by ~55% and ~30%, respectively. Modestly affected hyperglycaemia and blood pressure. Lowered the body weight.
体外研究:
LR-90 (0, 25, 50, 100, and 200 μM) inhibits RAGE, MCP-1, COX-2, IP-10 and NOX2 mRNA expression in THP-1 cells in a dose-dependent manner, after pretreatment 1 h befor S100b stimulatation for 4 hours.LR-90 (0, 25, 50, 100, and 200 μM) dose-dependently and significantly blocks THP-1 cells adherence to endothelial cells after pretreatment 1 h befor S100b stimulatation for 24 hours.LR-90 (0, 25, 50, 100, and 200 μM, for 24 hours) shows no effect on the cell viability of THP-1 cells.