产品
编 号：F292188
分子式：C11H17NO8
分子量：291.25
分子式：C11H17NO8
分子量：291.25
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 24967-27-9
产品详情
生物活性：
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.
体内研究：
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg；腹腔注射；每天) 减轻小鼠模型中的肺纤维化。Animal Model:Mice (Mouse model of pulmonary fibrosis)
Dosage:10?mg/kg
Administration:I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result:Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
体外研究：
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 显著抑制 INS-1D 细胞中的唾液酸酶活性。
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity.
体内研究：
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10 mg/kg；腹腔注射；每天) 减轻小鼠模型中的肺纤维化。Animal Model:Mice (Mouse model of pulmonary fibrosis)
Dosage:10?mg/kg
Administration:I.p.; daily (starting at day 10 after Bleomycin, and then euthanized at day 21)
Result:Inhibition of sialidases starting at day 10 after bleomycin attenuates fibrosis.
体外研究：
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) (10-100 μM) 显著抑制 INS-1D 细胞中的唾液酸酶活性。
产品资料
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