产品
编 号：F292400
分子式：C18H21F3N2O3S
分子量：402.43
分子式：C18H21F3N2O3S
分子量：402.43
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 250266-51-4
产品详情
生物活性：
PNU-177864 is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 is structurally consistent with a cationic amphiphilic agent (CAD) and induces phospholipidosis in vivo. PNU-177864 antischizophrenic activity.
体内研究：
PNU-177864 (12.5-200 mg/kg；口服；每天；持续 2-4 周；Sprague-Dawley 大鼠) 治疗在狗或大鼠的异常靶器官 (包括附睾、垂体和毛囊) 中诱导磷脂沉积[ 1]。Animal Model:Male and female Sprague-Dawley rats (8-9-week-old)
Dosage:12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)
Administration:Oral gavage; daily; for 2-4 weeks
Result:Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
PNU-177864 is a potent, selective and orally active dopamine D3 receptor antagonist. PNU-177864 is structurally consistent with a cationic amphiphilic agent (CAD) and induces phospholipidosis in vivo. PNU-177864 antischizophrenic activity.
体内研究：
PNU-177864 (12.5-200 mg/kg；口服；每天；持续 2-4 周；Sprague-Dawley 大鼠) 治疗在狗或大鼠的异常靶器官 (包括附睾、垂体和毛囊) 中诱导磷脂沉积[ 1]。Animal Model:Male and female Sprague-Dawley rats (8-9-week-old)
Dosage:12.5 mg/kg, 50 mg/kg (for 2 weeks), or 200 mg/kg; 8 mg/kg, 25 mg/kg, or 80 mg/kg (for 4 weeks)
Administration:Oral gavage; daily; for 2-4 weeks
Result:Induced phospholipidosis in unusual target organs in dogs or rats including epididymis, pituitary, and hair follicles.
产品资料
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