产品
编 号：F293326
分子式：C15H12N2OS2
分子量：300.4
分子式：C15H12N2OS2
分子量：300.4
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
484
In-stock
10mg
880
In-stock
50mg
3520
In-stock
结构图
CAS No: 251992-66-2
产品详情
生物活性：
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases.
体内研究：
A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat.A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice.Animal Model:C57BL/6 mice
Dosage:10 mg/kg
Administration:Oral administration, 3 times per week, for 2 weeks
Result:Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells
Animal Model:Rat
Dosage:5 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:t1/2 = 1 hour
体外研究：
A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of152 μM.A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system.
A-205804 is an orally bioavailable, potent and selective lead inhibitor of E-selectin and ICAM-1 expression, with an IC50 of 20 nM and 25 nM for E-selectin and ICAM-1, respectively. A-205804 can be used in the research of chronic inflammatory diseases.
体内研究：
A-205804 (5 mg/kg; p.o.) shows a half-life of 1 hour for rat.A-205804 (10 mg/kg; p.o.; 3 times per week; for 2 weeks) attenuates the E-selectin expression on the endothelial vascular niche cells in mice.Animal Model:C57BL/6 mice
Dosage:10 mg/kg
Administration:Oral administration, 3 times per week, for 2 weeks
Result:Efficiently decreased the expression of E-selectin on the endothelial vascular niche cells
Animal Model:Rat
Dosage:5 mg/kg (Pharmacokinetic Analysis)
Administration:Oral administration
Result:t1/2 = 1 hour
体外研究：
A-205804 exhibits Cellular Toxicities for HUVEC with an IC50 of152 μM.A-205804 is an effective inhibitor of cell-cell adhesion in an in vitro flow experiment, demonstrating relevance in a model physiological system.
产品资料
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