产品
编 号：F293912
分子式：(C15H21O(C2H4O)m)n
分子式：(C15H21O(C2H4O)m)n
产品类型
规格
价格
是否有货
500mg
320
In-stock
1g
400
In-stock
结构图
CAS No: 25301-02-4
产品详情
生物活性：
Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals.
体内研究：
Tyloxapol 可用于动物建模，构建大鼠高脂血症模型。Animal Model:Twenty-one adult male Wistar rats, aged 11–12 weeks weighing 180-200 g.
Dosage:50 mg/kg.
Administration:Injected intraperitoneally, BW, every other day.
Result:Caused a significant (P?< 0.05) elevation in the levels of TBARS combined with an inhibition of the antioxidant enzymes (GPx, GST, CAT, SOD) in rat plasma, liver, and brain.Induced DNA fragmentation and inhibited the activities of acetylcholinesterase and mono aminoxidase in the brain.
体外研究：
Tyloxapol (100 μg/mL) 触发 HEK293 细胞脱离。Tyloxapol 诱导细胞核碎裂和凋亡细胞核的出现。Tyloxapol 会增加肺出血的风险，引起上皮细胞和红细胞的细胞毒性，并诱导人 Jurkat T 淋巴细胞裂解。
Tyloxapol (Triton WR1339) is a nonionic liquid polymer of the alkyl aryl polyether alcohol type, used as a surface active stabilizer. Tyloxapol (Triton WR1339) is used to induce hyperlipidemia in animals.
体内研究：
Tyloxapol 可用于动物建模，构建大鼠高脂血症模型。Animal Model:Twenty-one adult male Wistar rats, aged 11–12 weeks weighing 180-200 g.
Dosage:50 mg/kg.
Administration:Injected intraperitoneally, BW, every other day.
Result:Caused a significant (P?< 0.05) elevation in the levels of TBARS combined with an inhibition of the antioxidant enzymes (GPx, GST, CAT, SOD) in rat plasma, liver, and brain.Induced DNA fragmentation and inhibited the activities of acetylcholinesterase and mono aminoxidase in the brain.
体外研究：
Tyloxapol (100 μg/mL) 触发 HEK293 细胞脱离。Tyloxapol 诱导细胞核碎裂和凋亡细胞核的出现。Tyloxapol 会增加肺出血的风险，引起上皮细胞和红细胞的细胞毒性，并诱导人 Jurkat T 淋巴细胞裂解。
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