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编 号：F294776
分子式：C15H12O5
分子量：272.26
分子式：C15H12O5
分子量：272.26
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CAS No: 25515-46-2
产品详情
生物活性：
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell.
体内研究：
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice.(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.Animal Model:Mouse type I allergic model
Dosage:0.8 mg/kg
Administration:Oral administration
Result:Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.
Animal Model:Allergic airway inflammation induced in mice
Dosage:0.8 mg/kg
Administration:Oral administration, daily
Result:Decreased cell numbers of the infiltrating leukocyte and eosinophils.Decreased Muc5ac and gob-5 expression in the lungs.
体外研究：
(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50 value of 68 μg/mL.(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production.(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells.(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages.
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell.
体内研究：
(E)-Naringenin chalcone (0.8 mg/kg, oral administration) shows anti-allergic effect in type I allergic mice.(E)-Naringenin chalcone (0.8 mg/kg, oral administration) suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells in allergic airway inflammatory mice.Animal Model:Mouse type I allergic model
Dosage:0.8 mg/kg
Administration:Oral administration
Result:Inhibited the ear-swelling response, with the inhibitory ratio of 46.7%.
Animal Model:Allergic airway inflammation induced in mice
Dosage:0.8 mg/kg
Administration:Oral administration, daily
Result:Decreased cell numbers of the infiltrating leukocyte and eosinophils.Decreased Muc5ac and gob-5 expression in the lungs.
体外研究：
(E)-Naringenin chalcone (25-125 μg/mL, 10 min) inhibits histamine release from rat peritoneal mast cells, with an IC50 value of 68 μg/mL.(E)-Naringenin chalcone (25-50 μM, 8 days) improves adipocyte (3T3-L1) functions by enhancing adiponectin production.(E)-Naringenin chalcone (25-100 μM, 24 h) stimulates the activity of PPARγ in NIH-3T3 cells.(E)-Naringenin chalcone (0-200 μM 24 h) inhibits the production of TNF-alpha, MCP-1, and nitric oxide (NO) by LPS-stimulated RAW 264 macrophages.
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