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编 号:F295805
分子式:C32H46O16
分子量:686.7
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
Secoisolariciresinol diglucoside ((S,S)-SDG), the main lignan in wholegrain flaxseed, is known for its beneficial effects including anti-inflammatory, antioxidant, anti-mutagenic, anti-microbial, anti-obesity, hypolipidemic, and neuroprotective effects.

体内研究:
Secoisolariciresinol diglucoside (4 mg/mouse; a single p.o.) diminishes leukocyte adhesion and migration across blood-brain barrier (BBB) in neuroinflammation.Animal Model:Hand feeding mice (10 weeks old, male) are injected with TNFα
Dosage:4 mg/mouse
Administration:P.o. 2 h before i.c. administration of TNFα
Result:Attenuated adhesion of leukocytes to the endothelium by 50% and attenuated migration of leukocytes across the BBB by 64%.

体外研究:
Secoisolariciresinol diglucoside (1-500 μM) possesses strong reducing power and high free radical scavenging activity for hydroxyl, peroxyl and DPPH free radicals.Secoisolariciresinol diglucoside (1-50 μM; 24 h) attenuates human monocyte adhesion to and migration across human brain endothelial monolayers.
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