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编 号：F295975
分子式：C18H31NO
分子量：277.44
分子式：C18H31NO
分子量：277.44
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CAS No: 25848-37-7
产品详情
生物活性：
4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer.
体内研究：
4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo.Animal Model:Specific pathogen-free athymic BALB/c nu/nu nude mice (6weeks of age, male)
Dosage:10, 15, 40 mg/kg
Administration:i.v., daily, for 2 weeks or i.p., single
Result:Suppressed tumor growth in PC-3-implanted mice in vivo.
体外研究：
4-(Dodecylamino)phenol (p-DDAP) (0-10 μM; 72 h) induces growth arrest in NB-39-nu cells.p-DDAP (0.1, 0.2, 0.4, 10 μM; ) arrestes the cell cycle in the G0/G1 phase in dose-dependent manner.p-DDAP (0.2 μM; 48 h) induces apoptotosis without differentiation.p-DDAP (0.2, 0.4, 1 μM; 24 h, 72 h) induces apoptotic cell death through bcl-2 down-regulation and caspases activation.
4-(Dodecylamino)phenol (p-DDAP) is an anticancer agent. 4-(Dodecylamino)phenol has anti-tumor activity and can suppress proliferation, arrest the cell cycle and induce apoptotic cell death. 4-(Dodecylamino)phenol can be used for the research of cancer, such as prostate cancer.
体内研究：
4-(Dodecylamino)phenol (p-DDAP) (10, 15, 40 mg/kg; i.v., daily, for 2 weeks or i.p., single) exhibits excellent anticancer efficacy against hormonal independent prostate cancer in vivo.Animal Model:Specific pathogen-free athymic BALB/c nu/nu nude mice (6weeks of age, male)
Dosage:10, 15, 40 mg/kg
Administration:i.v., daily, for 2 weeks or i.p., single
Result:Suppressed tumor growth in PC-3-implanted mice in vivo.
体外研究：
4-(Dodecylamino)phenol (p-DDAP) (0-10 μM; 72 h) induces growth arrest in NB-39-nu cells.p-DDAP (0.1, 0.2, 0.4, 10 μM; ) arrestes the cell cycle in the G0/G1 phase in dose-dependent manner.p-DDAP (0.2 μM; 48 h) induces apoptotosis without differentiation.p-DDAP (0.2, 0.4, 1 μM; 24 h, 72 h) induces apoptotic cell death through bcl-2 down-regulation and caspases activation.
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