产品
编 号：F296578
分子式：C48H48N32O16
分子量：1329.1
分子式：C48H48N32O16
分子量：1329.1
产品类型
规格
价格
是否有货
5mg
280
In-stock
10mg
424
In-stock
25mg
960
In-stock
50mg
1440
In-stock
结构图
CAS No: 259886-51-6
产品详情
生物活性：
Cucurbituril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbituril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbituril can induce energy transfer .
体内研究：
Cucurbituril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.
体外研究：
Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins.The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.
Cucurbituril is a potent, low toxicity and orally active supramolecular inducer of protein heterodimerization. Cucurbituril induces heterodimerization of methylviologen and naphthalene functionalized proteins. Cucurbituril can induce energy transfer .
体内研究：
Cucurbituril shows a very low toxicity of the in vivo intravenous injection, as well as oral administration studies on mice.
体外研究：
Cucurbituril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%.Cucurbituril indeed selectively induces the heterodimerization of MV–eYFP with Np–eCFP. Cucurbituril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbituril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbituril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins.The presence of Cucurbituril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces.
产品资料
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