产品
编 号：F298163
分子式：C18H34O4
分子量：314.46
分子式：C18H34O4
分子量：314.46
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CAS No: 263399-35-5
产品详情
生物活性：
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.
体内研究：
12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷。Animal Model:Mice fed a high-fat diet
Dosage:1 μg/kg
Administration:Retro-orbitally injection; once daily for 2 weeks
Result:Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.Increased BAT-specific lipid uptake and improved oral lipid tolerance.Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
Animal Model:To explore the biosynthesis of (±)12, 13-dihome in mice in vivo
Dosage:
Administration:7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result:Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
12,13-DiHOME is a stimulator of Brown adipose tissue (BAT), as well as a thermogenic lipokine that activates BAT in response to cold. (±)12,13-DiHOME activates BAT fuel uptake and enhances cold tolerance, via promoting the translocation of the FA transporters FATP1 and CD36 to the cell membrane. (±)12,13-DiHOME can be used for research of metabolic disorders.
体内研究：
12,13-DiHOME (1 μg/kg；眼球后注射；每天 1 次，共 2 周) 能显著降低小鼠高脂饮食模型中血清甘油三酯水平，并增加 BAT 的摄取以抵御寒冷。Animal Model:Mice fed a high-fat diet
Dosage:1 μg/kg
Administration:Retro-orbitally injection; once daily for 2 weeks
Result:Displayed no effects on body weight, glucose tolerance or circulating nonesterified FA.Increased BAT-specific lipid uptake and improved oral lipid tolerance.Increased radiolabeled FA uptake (Fig. 3f) and glucose uptake.
Animal Model:To explore the biosynthesis of (±)12, 13-dihome in mice in vivo
Dosage:
Administration:7-d cold challenge in mice: mice treated with norepinephrine (NE) for 30 min and exposed to 4°C-cold for 1 h
Result:Result: Increased in the circulation of male mice exposed to cold, but not female mice. And also, the enzymes producing 12,13-diHOME were uniquely induced in BAT by cold stimulation.
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