产品
编 号：F298456
分子式：C17H19F2N5O2S
分子量：395.43
分子式：C17H19F2N5O2S
分子量：395.43
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 264233-05-8
产品详情
生物活性：
CID 2745687 acts as a specific, reversible and competitive GPR35 antagonist with a Ki of 12.8 nM.
体内研究：
CID 2745687 (CID2745687; 1 mg/kg; administrated orally every day for the last 4 weeks), a specific GPR35 antagonist, reverses Lodoxamide-mediated anti-fibrotic effects.Animal Model:Six-week-old male C57BL/6 mice
Dosage:1 mg/kg
Administration:Oral administration, every day for 4 weeks
Result:Inhibited Lodoxamide-mediated protective effects.
体外研究：
For ERK1/2 phosphorylation with 1 μM Pamoic acid as the agonist, the CID 2745687 (CID2745687) Ki is 18 nM. CID 2745687 (CID-2745687) is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35.Using the BRET-based GPR35-β-arrestin-2 interaction assay and an EC80 concentration of Zaprinast (20 μM) as agonist, CID 2745687 behaved as a moderately potent, concentration-dependent antagonist at human GPR35 with pIC50=6.70±0.09.CID 2745687 (pIC50=6.27±0.08) fully reverses the agonist action of Cromolyn disodium .
CID 2745687 acts as a specific, reversible and competitive GPR35 antagonist with a Ki of 12.8 nM.
体内研究：
CID 2745687 (CID2745687; 1 mg/kg; administrated orally every day for the last 4 weeks), a specific GPR35 antagonist, reverses Lodoxamide-mediated anti-fibrotic effects.Animal Model:Six-week-old male C57BL/6 mice
Dosage:1 mg/kg
Administration:Oral administration, every day for 4 weeks
Result:Inhibited Lodoxamide-mediated protective effects.
体外研究：
For ERK1/2 phosphorylation with 1 μM Pamoic acid as the agonist, the CID 2745687 (CID2745687) Ki is 18 nM. CID 2745687 (CID-2745687) is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35.Using the BRET-based GPR35-β-arrestin-2 interaction assay and an EC80 concentration of Zaprinast (20 μM) as agonist, CID 2745687 behaved as a moderately potent, concentration-dependent antagonist at human GPR35 with pIC50=6.70±0.09.CID 2745687 (pIC50=6.27±0.08) fully reverses the agonist action of Cromolyn disodium .
产品资料
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