产品
编 号:F300298
分子式:C12H14N2O2
分子量:218.25
产品类型
结构图
CAS No: 26988-72-7
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产品详情
生物活性:
(Rac)-Indoximod (1-Methyl-DL-tryptophan) is an indoleamine 2,3-dioxygenase (IDO) inhibitor. Co-treatment with IFN-γ and (Rac)-Indoximod markedly reduces the activity of human cardiac myofibroblasts (hCMs) expressing α-SMA and induces apoptosis through up-regulating the IRF-1, Fas, and FasL genes.
体外研究:
(Rac)- Indoximod (1-甲基-DL-色氨酸;0.5 mM;3 天) 抑制色氨酸消除,从而部分逆转 IFN-γ 的生长抑制活性,但无论色氨酸耗尽如何,最终都会诱导细胞死亡。