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编 号：F300698
分子式：C23H25F3N2OS
分子量：434.52
分子式：C23H25F3N2OS
分子量：434.52
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CAS No: 2709-56-0
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生物活性：
Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.
体内研究：
Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice.Animal Model:BALB/C nude mice injected with A549 cells
Dosage:40 mg/kg
Administration:Intragastric injection; 40 mg/kg; once daily; 21 days
Result:Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).
体外研究：
Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner.Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells.Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels.
Flupentixol is an orally active D1/D2 dopamine receptor antagonist and new PI3K inhibitor (PI3Kα IC50=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research.
体内研究：
Flupentixol (intragastric injection; 40 mg/kg; once daily; 21 d) suppresses A549 xenografted tumor growth in nude mice.Animal Model:BALB/C nude mice injected with A549 cells
Dosage:40 mg/kg
Administration:Intragastric injection; 40 mg/kg; once daily; 21 days
Result:Reduced tumor volumes compared to the vehicle control (p<0.05), reduced tumor weights by 64.1% (p<0.05).
体外研究：
Flupentixol (2.5-40 μM; 72 h) treatment inhibits the viability of lung cancer cells in a dose-dependent manner.Flupentixol (2.5-40 μM; 24 h) induces apoptosis in lung cancer cells.Flupentixol (2.5-15 μM; 24 h) inhibits p-AKT and Bcl-2 expression levels.
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