产品
编 号：F303795
分子式：C24H27N3O4S
分子量：453.55
分子式：C24H27N3O4S
分子量：453.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
259
In-stock
5mg
680
In-stock
10mg
1080
In-stock
25mg
2160
In-stock
50mg
3600
In-stock
结构图
CAS No: 280749-17-9
产品详情
生物活性：
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.
体外研究：
A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site.
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively.
体外研究：
A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site.
产品资料
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