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编 号：F304474
分子式：C153H225N43O49S.ClH
分子量：3519.21
分子式：C153H225N43O49S.ClH
分子量：3519.21
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CAS No: 28270-04-4
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生物活性：
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation.
体内研究：
Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice.Animal Model:C57BL/6J mice (12- to 24-week-old)
Dosage:20 μg/kg and 1 mg/kg
Administration:Administered by i.p. injection; 45 minutes
Result:Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.
体外研究：
Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis.Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes.Glucagon (100 nM) increases phosphorylayion of HNF4α.
Glucagon (1-29), bovine, human, porcine hydrochloride is a peptide hormone, produced by pancreatic α-cells. Glucagon hydrochloride stimulates gluconeogenesis. Glucagon (1-29), bovine, human, porcine hydrochloride activates HNF4α and increases HNF4α phosphorylation.
体内研究：
Low-dose (20 μg/kg) Glucagon increases glycemia and does not stimulate insulin secretion in ambient-fed mice. High-dose (1 mg/kg) Glucagon lowers glycemia compared with PBS control and stimulates insulin secretion in ambient-fed mice.Animal Model:C57BL/6J mice (12- to 24-week-old)
Dosage:20 μg/kg and 1 mg/kg
Administration:Administered by i.p. injection; 45 minutes
Result:Low-dose (20 μg/kg) increased glycemia and did not stimulate insulin secretion.High-dose (1 mg/kg) lowered glycemia and stimulated insulin secretion.
体外研究：
Upon binding to its receptor Gcgr, Glucagon activates cAMP-PKA signaling to stimulate hepatic glucose production (HGP) and cause hyperglycemia. Glucagon stimulates both hepatic kisspeptin1 production and gluconeogenesis.Glucagon (100 nM) represses CYP7A1 mRNA expression in human primary hepatocytes.Glucagon (100 nM) increases phosphorylayion of HNF4α.
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