产品
编 号：F304642
分子式：C14H17FN2O2
分子量：264.3
分子式：C14H17FN2O2
分子量：264.3
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 283167-06-6
产品详情
生物活性：
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.
体内研究：
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.Animal Model:Male Lister Hooded rats, weighing approximately 270-300
Dosage:0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg
Administration:Administered i.p.
Result:Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.
体外研究：
FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.
体内研究：
FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease.Animal Model:Male Lister Hooded rats, weighing approximately 270-300
Dosage:0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg
Administration:Administered i.p.
Result:Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.
体外研究：
FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp.
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