产品
编 号：F304844
分子式：C40H68O11
分子量：724.96
分子式：C40H68O11
分子量：724.96
产品类型
规格
价格
是否有货
5mg
720
In-stock
10mg
1200
In-stock
25mg
2560
In-stock
50mg
询价
询价
结构图
CAS No: 28380-24-7
产品详情
生物活性：
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.
体内研究：
Nigericin (1 mg/kg；腹膜注射；每 12 h 一次，持续 3 天) 可减少小鼠 S. aureus USA300 菌的感染。Nigericin (0.025 mg/kg；皮下注射；每两天一次共四周) 协同 anti-PD-1 显示出协同抗癌作用。Animal Model:BALB/c Mice injected orthotopically with 4T1 cells
Dosage:0.025 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Showed combination with anti-PD-1 antibody almost completely suppressed tumor growth.
Animal Model:Mice Infected with S. aureus USA300
Dosage:1 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed reduction in the bacterial burden to 1,000-10,000-fold in the major organs.
体外研究：
Nigericin (0-4 μg/ml；24 小时) 通过 caspase 1/GSDMD 通路在 TNBC 细胞中诱导细胞焦亡 (pyroptosis)。Nigericin (0-0.25 μg/ml；24 小时) 是一种针对革兰氏阳性菌的抗生素。Nigericin (0-0.25 μg/ml；24 小时) 抑制 H460 细胞中的 Wnt/β-catenin 通路，发挥抗癌作用.
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/β-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC.
体内研究：
Nigericin (1 mg/kg；腹膜注射；每 12 h 一次，持续 3 天) 可减少小鼠 S. aureus USA300 菌的感染。Nigericin (0.025 mg/kg；皮下注射；每两天一次共四周) 协同 anti-PD-1 显示出协同抗癌作用。Animal Model:BALB/c Mice injected orthotopically with 4T1 cells
Dosage:0.025 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Showed combination with anti-PD-1 antibody almost completely suppressed tumor growth.
Animal Model:Mice Infected with S. aureus USA300
Dosage:1 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Showed reduction in the bacterial burden to 1,000-10,000-fold in the major organs.
体外研究：
Nigericin (0-4 μg/ml；24 小时) 通过 caspase 1/GSDMD 通路在 TNBC 细胞中诱导细胞焦亡 (pyroptosis)。Nigericin (0-0.25 μg/ml；24 小时) 是一种针对革兰氏阳性菌的抗生素。Nigericin (0-0.25 μg/ml；24 小时) 抑制 H460 细胞中的 Wnt/β-catenin 通路，发挥抗癌作用.
产品资料
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