产品
编 号：F305764
分子式：C24H27ClFN3O2
分子量：443.94
分子式：C24H27ClFN3O2
分子量：443.94
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 286369-38-8
产品详情
生物活性：
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.
体内研究：
S-14506 hydrochloride (0.2-3.38 mg/kg；IP；单剂量) 剂量依赖性拮抗 Apomorphine (0.75 mg/kg, s.c) 诱导的小鼠刻板攀登和嗅探。S-14506 hydrochloride 阻断多巴胺D2受体显示多巴胺拮抗剂特性。S-14506 hydrochloride (0.63 mg/kg；SC；单剂量) 在大鼠强迫游泳试验中有活性。它能诱导大鼠一动不动。Animal Model:Male swiss albino mice (25-30 g) and male Wistar rats (170-230 g)
Dosage:0.2 mg/kg, 0.8 mg/kg, 3.2 mg/kg, 3.8 mg/kg
Administration:IP; single dose, 30 min before test
Result:Inhibited stereotyped climbing and sniffing behaviours induced by dopamine agonists in mice and on spontaneous behaviours.
Animal Model:Male Wistar rats (200-220 g)
Dosage:0.01 mg/kg, 0.63 mg/kg
Administration:SC; and gave antagonist 30 min after agonist
Result:Induced a dose-dependent imobility in rats.
体外研究：
S-14506 hydrochloride 作为5-HT1A受体激动剂，似乎是 G(i) 蛋白依赖性。S-14506 hydrochloride (0.1 nM-100 μM；10 min) 在百日咳毒素处理的 HeLa 细胞中，对 5-HT 受体的 G 蛋白解偶联状态显示出高亲和力。
S-14506 hydrochloride is a potent 5-HT1A agonist, as well as 5-HT2A/2C antagonist. S-14506 hydrochloride displays dopamine antagonist properties by blocking dopamine D2 receptors. S-14506 hydrochloride inhibits the in vivo binding of [3H]raclopride in striatum and olfactory bulbs. S-14506 hydrochloride has the potential for the research of anxiolytic agent.
体内研究：
S-14506 hydrochloride (0.2-3.38 mg/kg；IP；单剂量) 剂量依赖性拮抗 Apomorphine (0.75 mg/kg, s.c) 诱导的小鼠刻板攀登和嗅探。S-14506 hydrochloride 阻断多巴胺D2受体显示多巴胺拮抗剂特性。S-14506 hydrochloride (0.63 mg/kg；SC；单剂量) 在大鼠强迫游泳试验中有活性。它能诱导大鼠一动不动。Animal Model:Male swiss albino mice (25-30 g) and male Wistar rats (170-230 g)
Dosage:0.2 mg/kg, 0.8 mg/kg, 3.2 mg/kg, 3.8 mg/kg
Administration:IP; single dose, 30 min before test
Result:Inhibited stereotyped climbing and sniffing behaviours induced by dopamine agonists in mice and on spontaneous behaviours.
Animal Model:Male Wistar rats (200-220 g)
Dosage:0.01 mg/kg, 0.63 mg/kg
Administration:SC; and gave antagonist 30 min after agonist
Result:Induced a dose-dependent imobility in rats.
体外研究：
S-14506 hydrochloride 作为5-HT1A受体激动剂，似乎是 G(i) 蛋白依赖性。S-14506 hydrochloride (0.1 nM-100 μM；10 min) 在百日咳毒素处理的 HeLa 细胞中，对 5-HT 受体的 G 蛋白解偶联状态显示出高亲和力。
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