产品
编 号：F306542
分子式：C22H37NO2
分子量：347.53
分子式：C22H37NO2
分子量：347.53
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 287937-12-6
产品详情
生物活性：
Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.
体内研究：
Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo.Animal Model:Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety
Dosage:1, 5 and 10 mg/kg
Administration:Intraperitoneal injection; 1-10 mg/kg; once
Result:Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
体外研究：
Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus.Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1.Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control.Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells.
Virodhamine is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. Virodhamine can be used for the research of various neurological disorders such as Alzheimer's and Parkinson's diseases.
体内研究：
Virodhamine (1-10 mg/kg; i.p. once) repairs the nicotine (0.8 mg/kg) and immobilization stress induced anxiety in vivo.Animal Model:Male ICR mice with nicotine (0.8 mg/kg) and immobilization stress induced anxiety
Dosage:1, 5 and 10 mg/kg
Administration:Intraperitoneal injection; 1-10 mg/kg; once
Result:Significantly repaired the working memory impairment-like behaviors s at a does of 5 mg/kg and showed significant anxiolytic-like effects against the anxiety-like behaviors at a does of 10 mg/kg.
体外研究：
Virodhamine (50 nM; 72 h) increases adherence, membrane expansion and the size of nucleus.Virodhamine (10-40 μM; 72 h) increases the expression level of CD61 and TRPV1.Virodhamine (72 h) inhibits the cell proliferation of megakaryocyte cells and significantly increases the portion of high ploidy cells as compared to control.Virodhamine significantly increases the protein expression level of CB2 receptorn, ROS production and NAPDH oxidase NOX4 expression in megakaryocytic cells.
产品资料
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