生物活性: IRBP (1-20), human contains a major epitope for the H-2b haplotype. IRBP (1-20), human induces experimental autoimmune uveoretinitis (EAU) in H-2b mice.
体内研究: IRBP (1-20), human TFA induces EAU.For determination of proliferative and cytokine responses, lymph node and spleen cells are collected 21 days after immunization and are stimulated in culture with the appropriate antigen. Cells of C57BL/6 mice and 129/J mice immunized with IRBP (1-20), human TFA proliferated in response to the peptide.Animal Model:C57BL/6 (H-2bDosage:200, 300 μg
Administration:I.h.; After 21 days
Result:C57BL/6 (H-2b