产品
编 号：F310629
分子式：C14H11N3O
分子量：237.26
分子式：C14H11N3O
分子量：237.26
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
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50mg
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100mg
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询价
结构图
CAS No: 300586-90-7
产品详情
生物活性：
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.
体内研究：
OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice.Animal Model:Irradiated NSG mice with OAC1 or vehicle control treated CB CD34+ cells within 24h after irradiation
Dosage:16 weeks
Administration:Subcutaneous injection OAC1(500 nM) treated CB CD34+ cells
Result:Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers.
体外研究：
OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies.OAC1 (1 μM; 2 d; human IMR90 fibroblast cells) activates endogenous Oct4, Nanog, Sox2, and Tet1 expression.OAC1 (500 nM; 4 d; CD34+ cells) increases numbers of phenotypic hematopoietic stem cells (HSC) and functional Hematopoietic progenitor cells (HPC).OAC1 (500 nM; 4 d; CD34+ cells) activates OCT4 through upregulation of HOXB4 expression to expand hematopoietic stem cells (HSC).
OAC1 is a potent Oct4 activator. OAC1 activates Oct4 and Nanog promoters and enhances induced pluripotent stem cells (iPSC) formation. OAC1 activates OCT4 through upregulation of HOXB4 expression. OAC1 increases transcription of the Oct4-Nanog-Sox2 triad and TET1. OAC1 facilitates the reprogramming of cells by enhancing efficiency and shortening the reprogramming time.
体内研究：
OAC1 (50000 CB CD34+ cells with OAC1(500 nM); i.h.; 16 weeks) enhances short and long-term engrafting hematopoietic stem cells (HSC) in irradiated NSG mice.Animal Model:Irradiated NSG mice with OAC1 or vehicle control treated CB CD34+ cells within 24h after irradiation
Dosage:16 weeks
Administration:Subcutaneous injection OAC1(500 nM) treated CB CD34+ cells
Result:Increased cord blood (CB) cells in primary recipients, compared to the vehicle control group, with the board increase for human B cells, T cells, and myeloid cells in the bone marrow (BM) of primary recipients, resulting in a significant expansion of SRC numbers.
体外研究：
OAC1 (10 μM; 7 d) enhances reprogramming efficiency. OAC1 increases induced pluripotent stem cells (iPSC) generation from mouse embryonic fibroblasts (MEFs) and accelerates the appearance of iPSC-like colonies.OAC1 (1 μM; 2 d; human IMR90 fibroblast cells) activates endogenous Oct4, Nanog, Sox2, and Tet1 expression.OAC1 (500 nM; 4 d; CD34+ cells) increases numbers of phenotypic hematopoietic stem cells (HSC) and functional Hematopoietic progenitor cells (HPC).OAC1 (500 nM; 4 d; CD34+ cells) activates OCT4 through upregulation of HOXB4 expression to expand hematopoietic stem cells (HSC).
产品资料
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