产品
编 号：F310654
分子式：C31H26N2O3
分子量：474.55
分子式：C31H26N2O3
分子量：474.55
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
690
In-stock
5mg
630
In-stock
10mg
1080
In-stock
25mg
2340
In-stock
结构图
CAS No: 300657-03-8
产品详情
生物活性：
BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.
体内研究：
BMS-309403 钠 (15 mg/kg；长期处理；每日一次，持续 6 周) 改善内皮功能、磷酸化和总 eNOS 并降低血浆甘油三酯水平，但不影响内皮非依赖性松弛。Animal Model:C57BL/6J mice (ApoE?/? mice)
Dosage:15 mg/kg
Administration:Chronic treatment ; daily for 6 weeks
Result:Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE?/? mice.
体外研究：
BMS-309403 处理以剂量和时间依赖性方式显著降低 THP-1 巨噬细胞产生的 MCP-1。
BMS-309403 is a potent, orally active and selective adipocyte fatty acid binding protein (also known as FABP4, aP2) inhibitor with Kis of <2, 250, and 350 nM for FABP4, FABP3, and FABP5, respectively. BMS-309403 interacts with the fatty-acid-binding pocket within the interior of the protein and competitively inhibits the binding of endogenous fatty acids. BMS-309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.
体内研究：
BMS-309403 钠 (15 mg/kg；长期处理；每日一次，持续 6 周) 改善内皮功能、磷酸化和总 eNOS 并降低血浆甘油三酯水平，但不影响内皮非依赖性松弛。Animal Model:C57BL/6J mice (ApoE?/? mice)
Dosage:15 mg/kg
Administration:Chronic treatment ; daily for 6 weeks
Result:Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE?/? mice.
体外研究：
BMS-309403 处理以剂量和时间依赖性方式显著降低 THP-1 巨噬细胞产生的 MCP-1。
产品资料
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