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编 号：F311636
分子式：C21H32O3
分子量：332.48
分子式：C21H32O3
分子量：332.48
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CAS No: 303-01-5
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生物活性：
Hydroxydione has an effect of general anesthetic. Hydroxydione is a neuroactive steroid it can be used for anaesthesia related research.
体内研究：
Hydroxydione increases the duration of hexobarbital narcosis and repeats hexobarbital doses decrease the duration of hydroxydione narcosis.Hydroxydione (5-100 mg/kg; i.v. once) produces a transient hypotension with little bradycardia and affects the respiration.Animal Model:Cats with chloralose 60 to 80 mg/kg
Dosage:5-100 mg/kg
Administration:Intravenous injection; 5-100 mg/kg once
Result:Produce severe respiratory depression, but showed no effect on the tibialis in response to excitation of its motor nerve under the condition of chloralose. Produced the usual substantial sustained hypotension seen in chloralosed cats to response the nictitating membrane topreganglionic excitation with a dose of 10 mg/kg. Repressed the respiration in chloralosed cats after a rapid injection.
Hydroxydione has an effect of general anesthetic. Hydroxydione is a neuroactive steroid it can be used for anaesthesia related research.
体内研究：
Hydroxydione increases the duration of hexobarbital narcosis and repeats hexobarbital doses decrease the duration of hydroxydione narcosis.Hydroxydione (5-100 mg/kg; i.v. once) produces a transient hypotension with little bradycardia and affects the respiration.Animal Model:Cats with chloralose 60 to 80 mg/kg
Dosage:5-100 mg/kg
Administration:Intravenous injection; 5-100 mg/kg once
Result:Produce severe respiratory depression, but showed no effect on the tibialis in response to excitation of its motor nerve under the condition of chloralose. Produced the usual substantial sustained hypotension seen in chloralosed cats to response the nictitating membrane topreganglionic excitation with a dose of 10 mg/kg. Repressed the respiration in chloralosed cats after a rapid injection.
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