产品
编 号：F312263
分子式：C8H9ClN4
分子量：196.64
分子式：C8H9ClN4
分子量：196.64
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规格
价格
是否有货
100mg
360
In-stock
500mg
784
In-stock
结构图
CAS No: 304-20-1
产品详情
生物活性：
Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage.
体内研究：
Hydralazine hydrochloride (5 mg/kg，腹腔注射，一天一次，持续 4-6 周) 对脊髓损伤小鼠具有促进再生的免疫调节作用。Hydralazine hydrochloride (14 mg/kg，补充于饮水持续 15 天) 可减少自发性高血压和正常血压大鼠的白细胞迁移。Animal Model:Spinal cord injury mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Improved not only motor function and hypersensitivity but also spontaneous pain and emotion response in SCI mice.Inhibited both of BMDM recruitment and acrolein accumulation in the lesion epicenter of spinal cord in mice.
Animal Model:Spontaneously hypertensive rats (SHR)
Dosage:14 mg/kg
Administration:Supplemented in drinking water
Result:Reduced systolic blood pressure values and the number of adherent and migrating leukocytes in SHR.Reduce the number of adherent and migrating leukocytes in SHR.Decreased the levels of ICAM-1 mRNA.
体外研究：
Hydralazine hydrochloride (40-600 μM, 24-48 h) 诱导 caspase 依赖性凋亡并激活白血病 T 细胞线粒体凋亡事件。Hydralazine hydrochloride (1 μM, 40 min) 阻止 H2O2 诱导的 ATCC-CCL2 细胞线粒体碎片和去极化。Hydralazine hydrochloride (3-100 μg/mL, 1-5 days) 抑制人腹膜间皮细胞增殖。
Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage.
体内研究：
Hydralazine hydrochloride (5 mg/kg，腹腔注射，一天一次，持续 4-6 周) 对脊髓损伤小鼠具有促进再生的免疫调节作用。Hydralazine hydrochloride (14 mg/kg，补充于饮水持续 15 天) 可减少自发性高血压和正常血压大鼠的白细胞迁移。Animal Model:Spinal cord injury mice
Dosage:5 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Improved not only motor function and hypersensitivity but also spontaneous pain and emotion response in SCI mice.Inhibited both of BMDM recruitment and acrolein accumulation in the lesion epicenter of spinal cord in mice.
Animal Model:Spontaneously hypertensive rats (SHR)
Dosage:14 mg/kg
Administration:Supplemented in drinking water
Result:Reduced systolic blood pressure values and the number of adherent and migrating leukocytes in SHR.Reduce the number of adherent and migrating leukocytes in SHR.Decreased the levels of ICAM-1 mRNA.
体外研究：
Hydralazine hydrochloride (40-600 μM, 24-48 h) 诱导 caspase 依赖性凋亡并激活白血病 T 细胞线粒体凋亡事件。Hydralazine hydrochloride (1 μM, 40 min) 阻止 H2O2 诱导的 ATCC-CCL2 细胞线粒体碎片和去极化。Hydralazine hydrochloride (3-100 μg/mL, 1-5 days) 抑制人腹膜间皮细胞增殖。
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