产品
编 号：F315531
分子式：C20H16N4O2S2
分子量：408.5
分子式：C20H16N4O2S2
分子量：408.5
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 312946-37-5
产品详情
生物活性：
LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease.
体内研究：
LDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats.Animal Model:12 to 14-week-old male Wistar rats
Dosage:0.1, 1 and 2 mg/kg
Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once
Result:Dose-dependently decreased mean arterial pressure of mice.
Animal Model:12 to 14- and 35 to 40-week-old male Wistar rats
Dosage:0.1, 1 and 2 mg/kg
Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once
Result:Decreased mean arterial pressure in old group more significant than young group.
体外研究：
LDN-27219 (30 μM; 12 min) promotes the closed conformation of TGase 2 to activates calcium-activated potassium channels in smooth muscle cells.?LDN-27219 (30 μM; 20-25 min) increases the response to acetylcholine in phenylephrine-contracted human subcutaneous arteries.
LDN-27219 is a reversible, slow-binding inhibitor of TGase. LDN-27219 inhibits human TGase with an IC50 value of 0.6 μM. LDN-27219 effectively decreases blood pressure and induces vasodilation, it can be used for the research of cardiovascular disease.
体内研究：
LDN-27219 (0.1-2 mg/kg; i.v. once) affects vivo arterial pressure and shows larger effects on older rats.Animal Model:12 to 14-week-old male Wistar rats
Dosage:0.1, 1 and 2 mg/kg
Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once
Result:Dose-dependently decreased mean arterial pressure of mice.
Animal Model:12 to 14- and 35 to 40-week-old male Wistar rats
Dosage:0.1, 1 and 2 mg/kg
Administration:Intravenous injection; 0.1, 1 and 2 mg/kg once
Result:Decreased mean arterial pressure in old group more significant than young group.
体外研究：
LDN-27219 (30 μM; 12 min) promotes the closed conformation of TGase 2 to activates calcium-activated potassium channels in smooth muscle cells.?LDN-27219 (30 μM; 20-25 min) increases the response to acetylcholine in phenylephrine-contracted human subcutaneous arteries.
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