产品
编 号：F316114
分子式：C11H7IN2O4
分子量：358.09
分子式：C11H7IN2O4
分子量：358.09
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
880
In-stock
5mg
800
In-stock
10mg
1120
In-stock
50mg
2064
In-stock
100mg
3192
In-stock
结构图
CAS No: 314054-00-7
产品详情
生物活性：
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING.
体内研究：
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice.Animal Model:WT type mice.
Dosage:750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:Intraperitoneally, once.
Result:Significantly reduced Serum levels of type I IFNs and IL-6.
体外研究：
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING.
体内研究：
C-176 (750/375 nmol C-176 per mouse in 200 μL corn oil) significantly reduces the CMA-mediated induction of serum levels of type I IFNs and IL-6., without significant toxicity.C-176 results in a significant reduction in serum levels of type I IFNs and in a strong suppression of inflammatory parameters in the heart, with no evident signs of overt toxicity Trex1?/? mice.C-176 demonstrates marked amelioration of various signs of systemic inflammation in Trex1?/? mice.Animal Model:WT type mice.
Dosage:750/375 nmol C-176 per mouse in 200 μL corn oil (~1.34/0.67 mg/mL).
Administration:Intraperitoneally, once.
Result:Significantly reduced Serum levels of type I IFNs and IL-6.
体外研究：
C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. Pretreatment with C-176 markedly reduce the CMA-mediated induction of serum levels of type I IFNs and IL-6.
产品资料
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