产品
编 号:F316748
分子式:C23H24F3N3O
分子量:415.45
产品类型
结构图
CAS No: 315698-17-0
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产品详情
生物活性:
ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.
体外研究:
ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50ML311 相关抗体: