产品
编 号：F316758
分子式：C15H13N3S
分子量：267.35
分子式：C15H13N3S
分子量：267.35
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
结构图
CAS No: 315702-99-9
产品详情
生物活性：
STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively).
体内研究：
STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells.Animal Model:SCID mice implanted with SN12C-VHL shRNA cells
Dosage:2.7 mg/kg, or 8 mg/kg
Administration:Intraperitoneal injection; daily; for 9 days
Result:Significantly reduced tumor growth of VHL-deficient cells.
体外研究：
In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts.STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells.
STF-62247 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively).
体内研究：
STF-62247 (2.7-8 mg/kg; intraperitoneal injection; daily; for 9 days) treatment significantly reduces tumor growth of VHL-deficient cells.Animal Model:SCID mice implanted with SN12C-VHL shRNA cells
Dosage:2.7 mg/kg, or 8 mg/kg
Administration:Intraperitoneal injection; daily; for 9 days
Result:Significantly reduced tumor growth of VHL-deficient cells.
体外研究：
In RCC4, RCC4/VHL, SN12C, SN12C-VHL shRNA cells, STF-62247 (0-30 μM) is selectively toxic to VHL-deficient cells compared to their VHL wild-type counterparts.STF-62247-treated cells accumulated intracytoplasmic vacuoles characteristic of cells undergoing autophagy. Moreover, these vacuoles are larger in VHL-deficient RCC4 and SN12C-VHL shRNA cells than in wild-type VHL cells.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备