产品
编 号：F317562
分子式：C4H8ClNOS
分子量：153.63
分子式：C4H8ClNOS
分子量：153.63
产品类型
规格
价格
是否有货
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 31828-68-9
产品详情
生物活性：
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice.
体内研究：
L-Homocysteine thiolactone hydrochloride (1 μL；200 μM；玻璃体内) 诱导 HHcy (高同型半胱氨酸血症)升高。Animal Model:cbs+/- mice and normal wild type mice (C57BL6/J), 6-8 weeks of age
Dosage:1 μL; 200 μM
Administration:Intravitreally
Result:Normal retinal flat-mount preparations from cbs+/+ mice showed quiescent ramified microglia, while cbs-/- and cbs+/- retinas demonstrated rod-like microglia devoid of branching processes, indicating microglia activation in HHcy mice.
体外研究：
L-Homocysteine thiolactone hydrochloride (20 μM；持续 24 小时) 显示促炎细胞因子 IP-10、TNFα、IL-1β 和 IL6 显着增加。L-Homocysteine thiolactone hydrochloride (100 μM；24 小时) 显示核/细胞质 NF-κB 的比率显着升高，表明同型半胱氨酸 (Hcy) 诱导 NF-κB 激活和核转位。
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice.
体内研究：
L-Homocysteine thiolactone hydrochloride (1 μL；200 μM；玻璃体内) 诱导 HHcy (高同型半胱氨酸血症)升高。Animal Model:cbs+/- mice and normal wild type mice (C57BL6/J), 6-8 weeks of age
Dosage:1 μL; 200 μM
Administration:Intravitreally
Result:Normal retinal flat-mount preparations from cbs+/+ mice showed quiescent ramified microglia, while cbs-/- and cbs+/- retinas demonstrated rod-like microglia devoid of branching processes, indicating microglia activation in HHcy mice.
体外研究：
L-Homocysteine thiolactone hydrochloride (20 μM；持续 24 小时) 显示促炎细胞因子 IP-10、TNFα、IL-1β 和 IL6 显着增加。L-Homocysteine thiolactone hydrochloride (100 μM；24 小时) 显示核/细胞质 NF-κB 的比率显着升高，表明同型半胱氨酸 (Hcy) 诱导 NF-κB 激活和核转位。
产品资料
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