产品
编 号：F318116
分子式：C6H6ClNO2S
分子量：191.64
分子式：C6H6ClNO2S
分子量：191.64
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 320386-54-7
产品详情
生物活性：
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.
体内研究：
SKF-34288 hydrochloride (37.5-150mg/kg, 口服) 降低饥饿大鼠的血糖。SKF-34288 hydrochloride (25 mg/kg，皮下注射) 中和沙丁胺醇介导的兔子高血糖症。SKF-34288 hydrochloride (30 和 300 mg/kg，腹腔注射) 降低丙酮酸诱导的大鼠血糖水平。Animal Model:Starved rats
Dosage:37.5, 75 and 150mg/kg
Administration:Oral administration (p.o.)
Result:Showed dose-dependent magnitude and duration of the hypoglycaemic effect.
体外研究：
SKF-34288 hydrochloride (0.01-1 mM, 48 h) 抑制 C2C12 细胞增殖。SKF-34288 hydrochloride (0.25-1 mM，0-5 天) 诱导 C2C12 细胞的肌原性分化。SKF-34288 hydrochloride (0.25 或 1 mM) 降低 Pck2 和丝氨酸生物合成相关基因的 mRNA 表达。
SKF-34288 (3-Mercaptopicolinic acid) hydrochloride is an orally active phosphoenolpyruvate carboxykinase (PEPCK) inhibitor (Ki: 2-9 μM). SKF-34288 hydrochloride is a potent hypoglycemic agent by inhibiting glucose synthesis. SKF-34288 hydrochloride also inhibits Asn metabolism and increases amino acids and amides.
体内研究：
SKF-34288 hydrochloride (37.5-150mg/kg, 口服) 降低饥饿大鼠的血糖。SKF-34288 hydrochloride (25 mg/kg，皮下注射) 中和沙丁胺醇介导的兔子高血糖症。SKF-34288 hydrochloride (30 和 300 mg/kg，腹腔注射) 降低丙酮酸诱导的大鼠血糖水平。Animal Model:Starved rats
Dosage:37.5, 75 and 150mg/kg
Administration:Oral administration (p.o.)
Result:Showed dose-dependent magnitude and duration of the hypoglycaemic effect.
体外研究：
SKF-34288 hydrochloride (0.01-1 mM, 48 h) 抑制 C2C12 细胞增殖。SKF-34288 hydrochloride (0.25-1 mM，0-5 天) 诱导 C2C12 细胞的肌原性分化。SKF-34288 hydrochloride (0.25 或 1 mM) 降低 Pck2 和丝氨酸生物合成相关基因的 mRNA 表达。
产品资料
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