产品
编 号:F321324
分子式:C32H46N8O6S2
分子量:702.89
产品类型
结构图
CAS No: 3286-46-2
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产品详情
生物活性:
Sulbutiamine is a synthetic analogue of vitamin B1 used for the treatment of asthenia.
体外研究:
Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Sulbutiamine enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH and GST activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF.