产品
编 号：F322200
分子式：C15H28N4O4
分子量：328.41
分子式：C15H28N4O4
分子量：328.41
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
50mg
询价
询价
100mg
询价
询价
结构图
CAS No: 330600-85-6
产品详情
生物活性：
Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19.
体内研究：
Peramivir (20-60 mg/kg，腹腔注射，单次剂量) 可抑制 LPS 诱导的细胞因子风暴，减轻急性肺损伤，延长细胞因子风暴综合征模型小鼠的生存时间。Peramivir (75 mg/kg，肌肉注射，每天 1 次，连续 7 天) 在 B 型流感病毒感染的免疫抑制小鼠模型中拯救了 BR/08 致死性攻击的 BALB scid 小鼠。Animal Model:Cytokine storm syndrome model mice
Dosage:20 mg/kg, 60 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased 8 cytokines including TNF-a, IFN-a, IFN-γ, chemokines (MCP-1), GM-CSF, IL-1β, IL-6 and IL-12.Showed less inflammatory cell infiltrations, mild alveolar thickening and less bleeding points or congestion.Showed significant protective effects to the lung tissues.
Animal Model:Immunocompromised murine models of infuenza B virus infection
Dosage:75 mg/kg
Administration:Intramuscular injection (i.m.)
Result:Conferred complete protection against lethality, whether it was administered in one (1×), two (2×), or four (4×) doses, with maximum mean weight loss of 10% to 14%.Resulted in a trend of decreasing virus replication in the nasal cavities and lungs.Reduced the virus titers and replication.
体外研究：
Peramivir (0.3125-40 μM, 4 h) 对巨噬细胞无毒性。Peramivir (2-10 μM, 6-12 h) 抑制 LPS 诱导的 hPBMCs 细胞因子释放。
Peramivir is an novel cyclopentane neuraminidase inhibitor of influenza virus. Peramivir has antiviral activity and anti-cytokines stom effects. Peramivir can be used for the research of COVID-19.
体内研究：
Peramivir (20-60 mg/kg，腹腔注射，单次剂量) 可抑制 LPS 诱导的细胞因子风暴，减轻急性肺损伤，延长细胞因子风暴综合征模型小鼠的生存时间。Peramivir (75 mg/kg，肌肉注射，每天 1 次，连续 7 天) 在 B 型流感病毒感染的免疫抑制小鼠模型中拯救了 BR/08 致死性攻击的 BALB scid 小鼠。Animal Model:Cytokine storm syndrome model mice
Dosage:20 mg/kg, 60 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Decreased 8 cytokines including TNF-a, IFN-a, IFN-γ, chemokines (MCP-1), GM-CSF, IL-1β, IL-6 and IL-12.Showed less inflammatory cell infiltrations, mild alveolar thickening and less bleeding points or congestion.Showed significant protective effects to the lung tissues.
Animal Model:Immunocompromised murine models of infuenza B virus infection
Dosage:75 mg/kg
Administration:Intramuscular injection (i.m.)
Result:Conferred complete protection against lethality, whether it was administered in one (1×), two (2×), or four (4×) doses, with maximum mean weight loss of 10% to 14%.Resulted in a trend of decreasing virus replication in the nasal cavities and lungs.Reduced the virus titers and replication.
体外研究：
Peramivir (0.3125-40 μM, 4 h) 对巨噬细胞无毒性。Peramivir (2-10 μM, 6-12 h) 抑制 LPS 诱导的 hPBMCs 细胞因子释放。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备