产品
编 号：F322253
分子式：C47H51NO14
分子量：853.91
分子式：C47H51NO14
分子量：853.91
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
458
In-stock
5mg
260
In-stock
10mg
416
In-stock
50mg
720
In-stock
100mg
1200
In-stock
500mg
2800
In-stock
结构图
CAS No: 33069-62-4
产品详情
生物活性：
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
体内研究：
Paclitaxel (1 -20 mg/kg；腹腔注射；1次/2天，共5个周期) 在低 Paclitaxel 组明显诱导肝转移，对原发肿瘤生长影响不大。Animal Model:MDA-231 xenograft-bearing mice
Dosage:1, 20 mg/kg
Administration:Intraperitoneal injection; five cycles (1 time/2 days)
Result:Liver metastases were obviously induced in the low-PTX (1 mg/kg) group with little influence on primary tumor growth compared with high-PTX group.
体外研究：
Paclitaxel (20 nM；48 h) 诱导程序性细胞死亡，并在细胞周期的 G2/M 期存在阻滞。 Paclitaxel (20 nM；48 hours) 诱导 p53 水平的持续增加。
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy.
体内研究：
Paclitaxel (1 -20 mg/kg；腹腔注射；1次/2天，共5个周期) 在低 Paclitaxel 组明显诱导肝转移，对原发肿瘤生长影响不大。Animal Model:MDA-231 xenograft-bearing mice
Dosage:1, 20 mg/kg
Administration:Intraperitoneal injection; five cycles (1 time/2 days)
Result:Liver metastases were obviously induced in the low-PTX (1 mg/kg) group with little influence on primary tumor growth compared with high-PTX group.
体外研究：
Paclitaxel (20 nM；48 h) 诱导程序性细胞死亡，并在细胞周期的 G2/M 期存在阻滞。 Paclitaxel (20 nM；48 hours) 诱导 p53 水平的持续增加。
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