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编 号:F322365
分子式:C118H202N34O31S2
分子量:2657.21
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生物活性:
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) has anti-apoptotic and neuroprotective functions.

体内研究:
(Gly14)-Humanin (human)(0.1 μg/5 μL;i.c.v.;一次)减少受损皮层和海马体中具有质膜通透性的细胞,减少脑损伤体积,改善运动性能并改善莫里斯水迷宫试验中的性能。Animal Model:Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)
Dosage:0.1 μg/5 μL
Administration:Intracerebroventricularly (i.c.v.); once
Result:Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.

体外研究:
(Gly14)-Humanin (human) (0.1-10 μM; 72 hours) 显着增加细胞活力,降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值 。并降低 bax 的mRNA水平,增加 bcl-2 的 mRNA 水平。
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