产品
编 号：F327528
分子式：C16H14O5
分子量：286.28
分子式：C16H14O5
分子量：286.28
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CAS No: 34000-39-0
产品详情
生物活性：
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.
体外研究：
Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells.Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells.Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%.Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively.
Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation.
体外研究：
Homobutein (compound 15) (20, 24, 28, 32, 40 μM; 2 h) inhibits the viability of K562 cells.Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells.Homobutein (1 μg/mL; 72 h) inhibits the growth of Toxoplasma gondii by 19.48%.Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively.
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