产品
编 号：F328536
分子式：C23H28N2O5
分子量：412.48
分子式：C23H28N2O5
分子量：412.48
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CAS No: 34274-91-4
产品详情
生物活性：
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines.
体内研究：
Gardneramine (4 mg/kg; 静脉注射; 单剂量) 在兔子中导致血压下降 (36.6%)。Gardneramine (0.2 mg/kg, 0.4 mg/kg; 动脉注射; 单剂量) 在狗的后肢中增加血液流速，产生血管扩张作用。Gardneramine (20 mg/kg, 40 mg/kg, and 80 mg/kg; 腹腔注射; 单剂量) 在小鼠中抑制胃和肠等平滑肌器官的运动。Gardneramine (20 mg/kg; 口服; 单剂量) 处理小鼠后摘除小肠，显示出松弛作用，轻微抑制应激性离子产生。
体外研究：
Gardneramine (80 μg/mL; 0-20 min) 对豚鼠的心房产生抑制作用。
Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines.
体内研究：
Gardneramine (4 mg/kg; 静脉注射; 单剂量) 在兔子中导致血压下降 (36.6%)。Gardneramine (0.2 mg/kg, 0.4 mg/kg; 动脉注射; 单剂量) 在狗的后肢中增加血液流速，产生血管扩张作用。Gardneramine (20 mg/kg, 40 mg/kg, and 80 mg/kg; 腹腔注射; 单剂量) 在小鼠中抑制胃和肠等平滑肌器官的运动。Gardneramine (20 mg/kg; 口服; 单剂量) 处理小鼠后摘除小肠，显示出松弛作用，轻微抑制应激性离子产生。
体外研究：
Gardneramine (80 μg/mL; 0-20 min) 对豚鼠的心房产生抑制作用。
产品资料
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