产品
编 号：F329995
分子式：C11H13ClF3N3O4S3
分子量：439.88
分子式：C11H13ClF3N3O4S3
分子量：439.88
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 346-18-9
产品详情
生物活性：
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity.
体内研究：
Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increases plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse.Polythiazide (oral administration, 0.4 mg/kg) shows diuretic and saluretic effects in hypertensive dogs and rats.Animal Model:Cholesterol-fed C57BL/cdJ mice
Dosage:10 mg/kg
Administration:Oral gavage, daily for 5 days
Result:Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction.
Animal Model:Hypertensive dogs
Dosage:0.4 mg/kg
Administration:Oral administration, daily for 5 days
Result:Increased in excretion of sodium and chloride.
Animal Model:Hypertensive rats
Dosage:0.05, 0.1, 0.2, 0.4 mg/kg
Administration:Oral administration, twice a day for 3 days.
Result:Displayed natriuretic and chloruretic effects.
体外研究：
Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM).
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity.
体内研究：
Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increases plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse.Polythiazide (oral administration, 0.4 mg/kg) shows diuretic and saluretic effects in hypertensive dogs and rats.Animal Model:Cholesterol-fed C57BL/cdJ mice
Dosage:10 mg/kg
Administration:Oral gavage, daily for 5 days
Result:Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction.
Animal Model:Hypertensive dogs
Dosage:0.4 mg/kg
Administration:Oral administration, daily for 5 days
Result:Increased in excretion of sodium and chloride.
Animal Model:Hypertensive rats
Dosage:0.05, 0.1, 0.2, 0.4 mg/kg
Administration:Oral administration, twice a day for 3 days.
Result:Displayed natriuretic and chloruretic effects.
体外研究：
Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM).
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