产品
编 号：F330666
分子式：C15H16N2O6S2
分子量：384.43
分子式：C15H16N2O6S2
分子量：384.43
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CAS No: 34787-01-4
产品详情
生物活性：
Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.
体内研究：
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect.Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment.Animal Model:Swiss type male mice injected with Ps. aeruginosa
Dosage:50, 100, 200 mg/kg
Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:Increased effect significantly (0.001 < P < 0.0025) with increasing dose.
Animal Model:Swiss type male mice injected with Ps. aeruginosa
Dosage:50, 100, 200 mg/kg
Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:Dose (mg/kg)AUCa (mg/kg) Kelb (h-1) T1/2 (min)
Ticarcillin508.76 (0.72)1.57 (0.18)26
10026.14 (0.60)1.53 (0.11)27
20054.56 (2.90)1.47 (0.12)28
体外研究：
Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities.
Ticarcillin is a semisynthetic, extended-spectrum, carboxypenicillin antibacterial agent, and is active against gram-positive cocci, including streptococci and staphylococci. Ticarcillin is also effective against most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin can be used in lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intraabdominal infections research.
体内研究：
Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows a dose-dependent antibacterial effect.Ticarcillin (Subcutaneous injection; 50, 100, 200 mg/kg; once) treatment shows excellent pharmacokinetic assessment.Animal Model:Swiss type male mice injected with Ps. aeruginosa
Dosage:50, 100, 200 mg/kg
Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:Increased effect significantly (0.001 < P < 0.0025) with increasing dose.
Animal Model:Swiss type male mice injected with Ps. aeruginosa
Dosage:50, 100, 200 mg/kg
Administration:Subcutaneous injection; 50, 100, 200 mg/kg; once
Result:Dose (mg/kg)AUCa (mg/kg) Kelb (h-1) T1/2 (min)
Ticarcillin508.76 (0.72)1.57 (0.18)26
10026.14 (0.60)1.53 (0.11)27
20054.56 (2.90)1.47 (0.12)28
体外研究：
Ticarcillin treatment (10 mg/L; 18 h) shows antibacterial activities.
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