产品
编 号：F335604
分子式：C23H18BrN3O3
分子量：464.31
分子式：C23H18BrN3O3
分子量：464.31
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
询价
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25mg
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结构图
CAS No: 359600-10-5
产品详情
生物活性：
RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity.
体外研究：
RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells. RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection.RNPA1000 (IC50=?100-125 μM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 μM), but does mildly inhibit E. coli RNase III activity (IC50=?500-750 μM).
RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity.
体外研究：
RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells. RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection.RNPA1000 (IC50=?100-125 μM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 μM), but does mildly inhibit E. coli RNase III activity (IC50=?500-750 μM).
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