产品
编 号：F337930
分子式：C22H30Cl4N2
分子量：464.3
分子式：C22H30Cl4N2
分子量：464.3
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 366-93-8
产品详情
生物活性：
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
体内研究：
AY 9944 (7.5 mg/kg；从产后第 2 天到产后第 20 天，每 6 天一次 ih) 在停止治疗后 400 天内降低脑胆固醇。Animal Model:Long–Evans hooded rats.
Dosage:7.5 mg/kg
Administration:Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20
Result:Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.
体外研究：
AY 9944 (1 μg/mL；15 h) 影响角质形成细胞中游离甾醇的类型。
AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
体内研究：
AY 9944 (7.5 mg/kg；从产后第 2 天到产后第 20 天，每 6 天一次 ih) 在停止治疗后 400 天内降低脑胆固醇。Animal Model:Long–Evans hooded rats.
Dosage:7.5 mg/kg
Administration:Subcutaneous injection; 7.5 mg/kg every 6 days once; from postnatal day 2 to postnatal day 20
Result:Reduced brain cholesterol and increased 7-dehydrocholesterol in all brain regions of rats till the treatment stopped for 400 days and showed a more severe effect on the change of sterols in plasma and liver of female rats.
体外研究：
AY 9944 (1 μg/mL；15 h) 影响角质形成细胞中游离甾醇的类型。
产品资料
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