产品
编 号：F338678
分子式：C16H13N3O4
分子量：311.29
分子式：C16H13N3O4
分子量：311.29
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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25mg
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50mg
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100mg
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结构图
CAS No: 36945-98-9
产品详情
生物活性：
Icilin?(AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel.?Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a “super-cooling agent”. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response.
体内研究：
Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin?(3 mg/kg; s.c.) induces“Wet dog shake” in mice.Animal Model:The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g).
Dosage:3 mg/kg
Administration:Injected s.c.
Result:Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.?
体外研究：
Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+?dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization.
Icilin?(AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel.?Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM). Icilin is a “super-cooling agent”. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response.
体内研究：
Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin?(3 mg/kg; s.c.) induces“Wet dog shake” in mice.Animal Model:The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g).
Dosage:3 mg/kg
Administration:Injected s.c.
Result:Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.?
体外研究：
Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+?dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization.
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