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编 号：F340077
分子式：C17H19NaO6
分子量：342.32
分子式：C17H19NaO6
分子量：342.32
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CAS No: 37415-62-6
产品详情
生物活性：
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.
体内研究：
Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodiumexerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice.Animal Model:Athymic 8-week-old, 20 g BALB/c nu/nu mice bearing Mycophenolic acid-resistant human U87 tumor model
Dosage:120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration:Oral gavage; b.i.d.
Result:MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (～70% after day 14 after tumor implantation) in MMF-treated versus control mice.Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).
体外研究：
Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus.IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides.Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC50 Mycophenolic acid sodium 相关抗体:Cell Proliferation AssayCell Line:Primary isolated human dermal microvascular endothelial cells (HDMVEC) , fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells,A549 non-small cell lung cancer cells.
Concentration:0.01, 0.1, 1 μM
Incubation Time:72 hours
Result:Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.
Western Blot AnalysisCell Line:HDMVEC
Concentration:0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time:18 hours
Result:Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.
Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.
体内研究：
Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodiumexerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice.Animal Model:Athymic 8-week-old, 20 g BALB/c nu/nu mice bearing Mycophenolic acid-resistant human U87 tumor model
Dosage:120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration:Oral gavage; b.i.d.
Result:MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (～70% after day 14 after tumor implantation) in MMF-treated versus control mice.Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).
体外研究：
Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus.IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides.Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC50 Mycophenolic acid sodium 相关抗体:Cell Proliferation AssayCell Line:Primary isolated human dermal microvascular endothelial cells (HDMVEC) , fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells,A549 non-small cell lung cancer cells.
Concentration:0.01, 0.1, 1 μM
Incubation Time:72 hours
Result:Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.
Western Blot AnalysisCell Line:HDMVEC
Concentration:0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time:18 hours
Result:Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.
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