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编 号:F341025
分子式:C27H44N10O6
分子量:604.7
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生物活性:
Antipain is a protease inhibitor isolated from Actinomycetes. Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain restricts uterine DNA synthesis and function in mice.

体内研究:
The intact, cycling female mice received subcutaneous injections of Antipain (3 mg) for 16 days, their uteri shows significant diminution in weight and total DNA when compared to untreated controls.Antipain (100 μg/g body wt; i.p.; at 12h intervals from 0 to 120 h or 240 to 360 h) shows inhibitory effect on Urethane-induced lung neoplasia in mice.
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