产品
编 号：F341262
分子式：C7H15Cl2N2O2P
分子量：261.09
分子式：C7H15Cl2N2O2P
分子量：261.09
产品类型
规格
价格
是否有货
200mg
480
In-stock
500mg
792
In-stock
结构图
CAS No: 3778-73-2
产品详情
生物活性：
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
体内研究：
Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.
体外研究：
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors.
体内研究：
Ifosfamide (50 mg/kg, i.p.) treatment before mating increases percentage of post-implantation loss and resorbs fetuses in pregnant rats. Ifosfamide also (50 mg/kg, i.p.) decreases the progesterone in the serum of pregnant rats. However, Ifosfamide causes no obvious difference with the control rats at 25 mg/kg. Ifosfamide (25, 50 mg/kg, i.p.) induces apoptosis and histological changes in the placentas and prenatal rats, most sensitive fetal organs are the brain, liver and kidney.
体外研究：
Ifosfamide is an alkylating chemotherapeutic agent with activity against a wide range of tumors. Ifosfamide is activated by the cytochrome P450 family. Ifosfamide (0-5 mM) suppresses the viability of CYP2B1-expressing C8III-1 cells, while it is cytotoxic to the non-CYP2B1-expressing CrFK cells only at high concentration (5 mM). CYP BM3 mutants activates Ifosfamide, and Ifosfamide shows inhibitory activity against human U2OS cells.
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