产品
编 号：F343361
分子式：C119H183N35O28S
分子量：2584.01
分子式：C119H183N35O28S
分子量：2584.01
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 383415-79-0
产品详情
生物活性：
Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
体内研究：
Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats.Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats.Animal Model:Male Harlan Sprague-Dawley rats, 250–300 g
Dosage:0.3, 1.0 and 3.0 nM
Administration:Intracerebroventricular injection, 2 μL
Result:Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model:Male Wistar rats weighing 250–300 g
Dosage:2, 4, 6 and 8 nM
Administration:Intra-cerebroventricular injection, 10 μL
Result:Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
体外研究：
Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC.
Neuropeptide W-23 (human) (NPW-23), the active form of Neuropeptide W, is an endogenous agonist of NPBW1 (GPR7) and NPBW2 (GPR8).
体内研究：
Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats.Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats.Animal Model:Male Harlan Sprague-Dawley rats, 250–300 g
Dosage:0.3, 1.0 and 3.0 nM
Administration:Intracerebroventricular injection, 2 μL
Result:Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model:Male Wistar rats weighing 250–300 g
Dosage:2, 4, 6 and 8 nM
Administration:Intra-cerebroventricular injection, 10 μL
Result:Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
体外研究：
Neuropeptide W-23 (human) (NPW-23) increases the ICa,L in transfected human embryonic kidney 293 cells and VSMCs via GPR7. Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC.
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备