产品
编 号:F343449
分子式:C15H11FN2O
分子量:254.26
产品类型
结构图
CAS No: 38376-29-3
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产品详情
生物活性:
VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus.
体外研究:
VU0420373 (compound 2e) has an IC50 of >60 μMfor Newman aerobic and Newman anaerobic, respectively. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM).