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编 号:F343449
分子式:C15H11FN2O
分子量:254.26
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10mM*1mL in DMSO
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5mg
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10mg
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25mg
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50mg
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100mg
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生物活性:
VU0420373 is a potent heme sensor system (HssRS) activator with an EC50 of 10.7 μM and a pEC50 of 4.97. VU0420373 induces heme biosynthesis, and is toxic to fermenting S. aureus.

体外研究:
VU0420373 (compound 2e) has an IC50 of >60 μMfor Newman aerobic and Newman anaerobic, respectively. VU0420373 (40 μM; 2, 4, 6, 8 hours) is able to preadapt S. aureus to a toxic concentration of heme (20 μM).
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