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编 号：F344180
分子式：C21H31O8P
分子量：442.44
分子式：C21H31O8P
分子量：442.44
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CAS No: 3863-59-0
产品详情
生物活性：
Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC).
体内研究：
Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.Animal Model:Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis
Dosage:30 mg/kg
Administration:P.o. twice daily for 5 days
Result:Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.Increased the body weight.
体外研究：
Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
Hydrocortisone phosphate (Hydrocortisone 21-phosphate), a physiological glucocorticoid, and is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone phosphate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone phosphate can be used for the research of ulcerative colitis (UC).
体内研究：
Hydrocortisone phosphate (30 mg/kg; p.o. twice daily for 5 d) reduces the weight loss and increases the food intake in mice.Animal Model:Male Sprague-Dawley rats (200-220 g, 10-11 weeks) are induced colitis
Dosage:30 mg/kg
Administration:P.o. twice daily for 5 days
Result:Significantly decreased the disease activity index (DAI) scores and myeloperoxidase (MPO) activity compared to the 2, 4, 6-trinitrobenzenesulfonic acid (TNBS) group.Increased the body weight.
体外研究：
Hydrocortisone phosphate inhibits IL-6 and IL-3 bioactivity, with IC50s of 6.7 and 21.4 μM, respectively, and shows no cytotoxic effects on IL-6-independent MH60 cells.Hydrocortisone phosphate (0.12-60 μM; 72 h) inhibits phytohemagglutinin (PHA) response in peripheral lymphocytes (PBL) and T-lymphocytes cultures.
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