产品
编 号：F348811
分子式：C13H8Cl2O4S
分子量：331.17
分子式：C13H8Cl2O4S
分子量：331.17
产品类型
规格
价格
是否有货
5mg
280
In-stock
10mg
464
In-stock
25mg
928
In-stock
50mg
1400
In-stock
100mg
2120
In-stock
结构图
CAS No: 40180-04-9
产品详情
生物活性：
Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro.
体内研究：
Tienilic acid (100 mg/lg in rats and mice, 5 mg/kg in pigs and dog; PO and IV; single dosage) is only found in plasma, eliminates by the biliary and the urinary fast, and exhibits small differences in the different species.Tienilic acid (0-480 mg/kg; PO; for 28 days) decreases blood pressure, serum, uric acidhemoglobin, and increased S-GPT; induces unicellular necrosis of small groups of liver cells.Animal Model:Rats, mice, pigs and dogs
Dosage:100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs
Administration:PO and IV; single dosage
Result:Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.
Animal Model:Female and male Sprague-Dawley rats
Dosage:0, 30, 120 and 480 mg/kg
Administration:PO; for 28 days
Result:Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.
Tienilic acid (Ticrynafen; ANP 3624) acts as a diuretic hypotensive agent. However, Tienilic acid induces hepatotoxicity. Tienilic acid is converted into electrophilic metabolites by cytochrome P450 (CYP) in vitro.
体内研究：
Tienilic acid (100 mg/lg in rats and mice, 5 mg/kg in pigs and dog; PO and IV; single dosage) is only found in plasma, eliminates by the biliary and the urinary fast, and exhibits small differences in the different species.Tienilic acid (0-480 mg/kg; PO; for 28 days) decreases blood pressure, serum, uric acidhemoglobin, and increased S-GPT; induces unicellular necrosis of small groups of liver cells.Animal Model:Rats, mice, pigs and dogs
Dosage:100 mg/lg in rats and mice, 5 mg/kg in pigs and dogs
Administration:PO and IV; single dosage
Result:Only found in plasma with important bindings to the plasma proteins at the blood level; pharmacological action for several hours; eliminated by the biliary and particularly the urinary fast, practically total in the first 48 hours after administration; only small differences were observed for the parameters measured in the different species.
Animal Model:Female and male Sprague-Dawley rats
Dosage:0, 30, 120 and 480 mg/kg
Administration:PO; for 28 days
Result:Decreased blood pressure and serum uric acid at 30 mg/kg; decreased slightly hemoglobin and increased S-GPT at 120 and 480 mg/kg; significantly increase the liver weight and serum magnesium concentration in male rats, while the liver weight of female rats increased only slightly; besides, induced unicellular necrosis of small groups of liver cells.
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