产品
编 号：F348864
分子式：C19H18F3N3O6
分子量：441.36
分子式：C19H18F3N3O6
分子量：441.36
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
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5mg
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10mg
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50mg
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100mg
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结构图
CAS No: 401900-40-1
产品详情
生物活性：
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.
体内研究：
GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively.GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a.Animal Model:Female C57BL/6J mice.
Dosage:0.5?mg/mouse.
Administration:Seven daily subcutaneous injections.
Result:Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC.Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.Did not detect any impact of GTx-007 on body weight.
GTx-007 (S-4) is an orally active and selective nonsteroidal androgen receptor (AR) modulator (SARM) and a partial agonist, with Ki of 4 nM. GTx-007 (S-4) is identified as SARMs with potent and tissue-selective in vivo pharmacological activity.
体内研究：
GTx-007 (S-4) is only a partial agonist in the prostate and seminal vesicles, restoring them to 33.8 and 28.2% of intact animals, respectively.GTx-007 significantly increased uterine expression of Wnt4 and Wnt7a.Animal Model:Female C57BL/6J mice.
Dosage:0.5?mg/mouse.
Administration:Seven daily subcutaneous injections.
Result:Resulted in a highly heterogeneous pattern of AR expression in all compartments, with a significant increase of AR-positive cells in the luminal epithelium compared to VC.Had approximately ten glands per uterine cross-section within an endometrium, with a compact stroma, consistent with overall endogenous steroid depletion.Did not detect any impact of GTx-007 on body weight.
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